Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration
Identifieur interne : 000229 ( Main/Exploration ); précédent : 000228; suivant : 000230Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration
Auteurs : Yuen-Sum Lau [États-Unis] ; Gaurav Patki [États-Unis] ; Kaberi Das-Panja [États-Unis] ; Wei-Dong Le [États-Unis] ; S. Omar Ahmad [États-Unis]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2011-04.
English descriptors
- KwdEn :
Abstract
The protective impact of exercise on neurodegenerative processes has not been confirmed, and the mechanisms underlying the benefit of exercise have not been determined in human Parkinson’s disease or in chronic animal disease models. This research examined the long‐term neurological, behavioral, and mechanistic consequences of endurance exercise in experimental chronic parkinsonism. We used a chronic 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced mouse model of Parkinson’s disease with moderate neurodegeneration and examined the effects of treadmill exercise on movement and balance coordination, changes in dopamine neuron biomarkers, mitochondrial functions, and neurotrophic factor activities in the nigrostriatal system. The exercise results were compared with those of the control and sedentary chronic parkinsonian animals. After 18 weeks of exercise training in the chronic parkinsonian mice, we observed a significant deterrence in the loss of neuronal dopamine‐producing cells and other functional indicators. The impaired movement and balance incoordination in the chronic parkinsonian mice were also markedly reduced following exercise. Mechanistic investigations revealed that the neuronal and behavioral recovery produced by exercise in the chronic parkinsonian mice was associated with an improved mitochondrial function and an increase in the brain region‐specific levels of brain‐derived and glial cell line‐derived neurotrophic factors. Our findings indicate that exercise not only produces neuronal and mitochondrial protection, it also boosts nigrostriatal neurotrophic factor levels in the chronic parkinsonian mice with moderate neurodegeneration. Therefore, modifying lifestyle with increased exercise activity would be a non‐pharmacological neuroprotective approach for averting neurodegenerative processes, as demonstrated in experimental chronic parkinsonism.
Url:
DOI: 10.1111/j.1460-9568.2011.07626.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration</title>
<author><name sortKey="Lau, Yuen Um" sort="Lau, Yuen Um" uniqKey="Lau Y" first="Yuen-Sum" last="Lau">Yuen-Sum Lau</name>
</author>
<author><name sortKey="Patki, Gaurav" sort="Patki, Gaurav" uniqKey="Patki G" first="Gaurav" last="Patki">Gaurav Patki</name>
</author>
<author><name sortKey="Das Anja, Kaberi" sort="Das Anja, Kaberi" uniqKey="Das Anja K" first="Kaberi" last="Das-Panja">Kaberi Das-Panja</name>
</author>
<author><name sortKey="Le, Wei Ong" sort="Le, Wei Ong" uniqKey="Le W" first="Wei-Dong" last="Le">Wei-Dong Le</name>
</author>
<author><name sortKey="Ahmad, S Omar" sort="Ahmad, S Omar" uniqKey="Ahmad S" first="S. Omar" last="Ahmad">S. Omar Ahmad</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:963389C1F0EAB819253624453753C00A4F447E29</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1111/j.1460-9568.2011.07626.x</idno>
<idno type="url">https://api.istex.fr/document/963389C1F0EAB819253624453753C00A4F447E29/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002404</idno>
<idno type="wicri:Area/Main/Curation">002078</idno>
<idno type="wicri:Area/Main/Exploration">000229</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration</title>
<author><name sortKey="Lau, Yuen Um" sort="Lau, Yuen Um" uniqKey="Lau Y" first="Yuen-Sum" last="Lau">Yuen-Sum Lau</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Patki, Gaurav" sort="Patki, Gaurav" uniqKey="Patki G" first="Gaurav" last="Patki">Gaurav Patki</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Das Anja, Kaberi" sort="Das Anja, Kaberi" uniqKey="Das Anja K" first="Kaberi" last="Das-Panja">Kaberi Das-Panja</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le, Wei Ong" sort="Le, Wei Ong" uniqKey="Le W" first="Wei-Dong" last="Le">Wei-Dong Le</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahmad, S Omar" sort="Ahmad, S Omar" uniqKey="Ahmad S" first="S. Omar" last="Ahmad">S. Omar Ahmad</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Occupational Therapy Education, Kansas University Medical Center, Kansas City, KS</wicri:regionArea>
<placeName><region type="state">Kansas</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">European Journal of Neuroscience</title>
<idno type="ISSN">0953-816X</idno>
<idno type="eISSN">1460-9568</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2011-04">2011-04</date>
<biblScope unit="volume">33</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="1264">1264</biblScope>
<biblScope unit="page" to="1274">1274</biblScope>
</imprint>
<idno type="ISSN">0953-816X</idno>
</series>
<idno type="istex">963389C1F0EAB819253624453753C00A4F447E29</idno>
<idno type="DOI">10.1111/j.1460-9568.2011.07626.x</idno>
<idno type="ArticleID">EJN7626</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0953-816X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine parkinsonism</term>
<term>endurance exercise</term>
<term>mitochondrial dysfunction</term>
<term>neuroprotection</term>
<term>neurotrophic factor</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The protective impact of exercise on neurodegenerative processes has not been confirmed, and the mechanisms underlying the benefit of exercise have not been determined in human Parkinson’s disease or in chronic animal disease models. This research examined the long‐term neurological, behavioral, and mechanistic consequences of endurance exercise in experimental chronic parkinsonism. We used a chronic 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced mouse model of Parkinson’s disease with moderate neurodegeneration and examined the effects of treadmill exercise on movement and balance coordination, changes in dopamine neuron biomarkers, mitochondrial functions, and neurotrophic factor activities in the nigrostriatal system. The exercise results were compared with those of the control and sedentary chronic parkinsonian animals. After 18 weeks of exercise training in the chronic parkinsonian mice, we observed a significant deterrence in the loss of neuronal dopamine‐producing cells and other functional indicators. The impaired movement and balance incoordination in the chronic parkinsonian mice were also markedly reduced following exercise. Mechanistic investigations revealed that the neuronal and behavioral recovery produced by exercise in the chronic parkinsonian mice was associated with an improved mitochondrial function and an increase in the brain region‐specific levels of brain‐derived and glial cell line‐derived neurotrophic factors. Our findings indicate that exercise not only produces neuronal and mitochondrial protection, it also boosts nigrostriatal neurotrophic factor levels in the chronic parkinsonian mice with moderate neurodegeneration. Therefore, modifying lifestyle with increased exercise activity would be a non‐pharmacological neuroprotective approach for averting neurodegenerative processes, as demonstrated in experimental chronic parkinsonism.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Kansas</li>
<li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Texas"><name sortKey="Lau, Yuen Um" sort="Lau, Yuen Um" uniqKey="Lau Y" first="Yuen-Sum" last="Lau">Yuen-Sum Lau</name>
</region>
<name sortKey="Ahmad, S Omar" sort="Ahmad, S Omar" uniqKey="Ahmad S" first="S. Omar" last="Ahmad">S. Omar Ahmad</name>
<name sortKey="Das Anja, Kaberi" sort="Das Anja, Kaberi" uniqKey="Das Anja K" first="Kaberi" last="Das-Panja">Kaberi Das-Panja</name>
<name sortKey="Le, Wei Ong" sort="Le, Wei Ong" uniqKey="Le W" first="Wei-Dong" last="Le">Wei-Dong Le</name>
<name sortKey="Patki, Gaurav" sort="Patki, Gaurav" uniqKey="Patki G" first="Gaurav" last="Patki">Gaurav Patki</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000229 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000229 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:963389C1F0EAB819253624453753C00A4F447E29 |texte= Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration }}
This area was generated with Dilib version V0.6.23. |